Rhinocerebral mucormycosis with cavernous sinus thrombosis: case report
Keywords:
mucormicosis, diabetes mellitus, zygomycetes, Rhizopus arrhizusAbstract
Mucormycosis is a highly invasive fungal infection that has stood out in recent decades, especially in immunosuppressed patients or with serious underlying or concomitant diseases; such as diabetes mellitus, hematological neoplasms, thalassemias, transplants, liver cirrhosis, kidney failure, immunodeficiencies. These mycoses are caused by opportunistic fungi of the order Mucorales, mainly Rhizopus spp, Lichtheimia spp, Mucor spp and Rhizomucor spp. They present with various clinical manifestations, including: cutaneous, pulmonary, gastrointestinal and rhinocerebral. The latter, in our case, was produced by Rhizopus arrhizus (R. Oryzae). This fungus has a predilection for ketoacidotic diabetic patients. It has a global distribution of 90%. The key to treatment is immediate aggressive debridement along with high doses of intravenous Amphotericin B. The prognosis in these patients is very unfavorable. We present a case of a male patient with decompensated diabetes mellitus with the evolution of a progressive, aggressive and fatal mycosis.
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