Clinical, epidemiological and hematological characterization of hospitalized patients with clinical suspicion of dengue
DOI:
https://doi.org/10.61997/bjm.v13i2.422Keywords:
dengue, virus, prevention, hematocrit, plateletsAbstract
Introduction: Dengue is one of the main viral diseases of epidemic nature. The study of the clinical, epidemiological and hematological characteristics is essential for the prevention, treatment and evolution of cases.
Objective: To characterize hospitalized patients with clinical suspicion of dengue from a clinical, epidemiological and hematological point of view.
Methods: A descriptive, cross-sectional study was carried out at the “Amalia Simoni” Provincial Hospital of Camagüey, Cuba, during the year 2022. The sample was made up of 157 hospitalized patients with clinical suspicion of dengue. The variables analyzed were: age group, sex, month of diagnosis, signs and symptoms, hematological variables, leukocyte differential formula and days of onset of symptoms.
Results: There was superiority in the age group of 40-49 years (28.7%) and in the male sex (50.3%). In the month of August, 33 patients (21.0%) were reported, while the main signs and symptoms were fever (90.4%) and headache (59.9%). Regarding hematological variables, the mean hematological variables, the mean hematocrit ranged between 0.42 and 0.48 L/l and the platelet count between 224 and 256 x 109/L. In relation to the differential formula, the average number of polymorphonuclear cells varied between 0.62 and 0.72% and that of lymphocytes between 0.28 and 0.36%.
Conclusions: The sample studied was characterized by the preponderance of patients in the fourth decade of life who presented hyperthermia as a fundamental clinical manifestation. The study of hematological variables was essential for the evolution of the cases.
Downloads
References
Sirisena PDN, Mahilkar S, Sharma C, Jain J, Sunil S. Concurrent dengue infections: Epidemiology & clinical implications. Indian J Med Res. 2021;154(5):669-779. Disponible en: http://dx.doi.org/10.4103/ijmr.IJMR_1219_18 DOI: https://doi.org/10.4103/ijmr.IJMR_1219_18
Khan J, Ghaffar A, Khan SA. The changing epidemiological pattern of Dengue in Swat, Khyber Pakhtunkhwa. PLoS One. 2018;13(4):e0195706. Disponible en: http://dx.doi.org/10.1371/journal.pone.0195706 DOI: https://doi.org/10.1371/journal.pone.0195706
Messina JP, Brady OJ, Golding N, Kraemer MUG, Wint GRW, Ray SE, et al. The current and future global distribution and population at risk of dengue. Nat Microbiol. 2020;4(9):1508-15. Disponible en: http://dx.doi.org/10.1038/s41564-019-0476-8 DOI: https://doi.org/10.1038/s41564-019-0476-8
Guzmán Tirado MG, Vázquez S, Álvarez M, Pelegrino JL, Ruiz Amores D, Martínez PA, et al. Vigilancia de laboratorio de dengue y otros arbovirus en Cuba, 1970-2017. Rev Cubana Med Trop [Internet]. 2020 [acceso 26/12/2023];71(1): e338. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0375-07602019000100008&lng=es
Prattay KMR, Sarkar MR, Shafiullah AZM, Islam MS, Raihan SZ, Sharmin N. A retrospective study on the socio-demographic factors and clinical parameters of dengue disease and their effects on the clinical course and recovery of the patients in a tertiary care hospital of Bangladesh. PLoS Negl Trop Dis. 2022;16(4):e0010297. Disponible en: http://dx.doi.org/10.1371/journal.pntd.0010297 DOI: https://doi.org/10.1371/journal.pntd.0010297
Bhatt P, Sabeena SP, Varma M, Arunkumar G. Current Understanding of the Pathogenesis of Dengue Virus Infection. Curr Microbiol. 2021;78(1):17-32. Disponible en: http://dx.doi.org/10.1007/s00284-020-02284-w DOI: https://doi.org/10.1007/s00284-020-02284-w
Beltrán Saínz R, Hernández Baguer R, Mena Grandales K, Savón George L. Complicaciones oculares asociadas a la fiebre por dengue. Revista Cubana de Oftalmología [Internet]. 2020 [acceso 26/12/2023];33(2):810. Disponible en: http://revoftalmologia.sld.cu/index.php/oftalmologia/article/view/810.
Cardl Artal F. Complicaciones neurológicas asociadas a la infección por el virus del dengue. Rev neurol [Internet]. 2019 [acceso 26/12/2023];69:113-22. Disponible en: https://temas.sld.cu/dengue/2019/12/01/complicaciones-neurologicas-asociadas-a-la-infeccion-por-el-virus-del-dengue/. DOI: https://doi.org/10.33588/rn.6903.2019140
Rodríguez Puga R, Pérez Díaz Y, Dueñas Rodríguez Y, Rodríguez Abalo OdC, Díaz Pérez L, Pérez Díaz OA. Características dermato-epidemiológicas de las manifestaciones cutáneas por dengue en niños. Folia Dermatológica Cubana [Internet]. 2023 [acceso 26/12/2023];16(1):[aprox. 17 p.]. Disponible en: https://revfdc.sld.cu/index.php/fdc/article/view/276
Dueñas Rodríguez Y, Rodríguez Puga R. Características de pacientes con prescripción médica de Tratho Dengue. Rev. Cub. Tecnol. Salud [Internet]. 2023 [acceso 26/12/2023];14(1):58-67. Disponible en: https://revtecnologia.sld.cu/index.php/tec/article/view/4037
World Medical Association. Declaration of Helsinki. Ethical Principles for Medical Research Involving Human Subjects. Clin Rev Educ [Internet]. 2013 [acceso 26/12/2023];310(20);2191-4. Disponible en: https://www.wma.net/wp-content/uploads/2016/11/DoH-Oct2013-JAMA.pdf DOI: https://doi.org/10.1001/jama.2013.281053
Adane T, Getawa S. Coagulation abnormalities in Dengue fever infection: A systematic review and meta-analysis. PLoS Negl Trop Dis. 2021;18;15(8):e0009666. DOI: http://dx.doi.org/10.1371/journal.pntd.0009666 DOI: https://doi.org/10.1371/journal.pntd.0009666
Araya Umaña L, Wilson Salazar E. Dengue hallazgos hematológicos y de imagen. Revista Médica de Costa Rica y Centroamerica [Internet]. 2016 [acceso 26/12/2023];12(2):[aprox. 12 p.]. Disponible en: https://www.medigraphic.com/pdfs/revmedcoscen/rmc-2016/rmc163at.pdf
Khan J, Adil M, Wang G, Tsheten T, Zhang D, Pan W, et al. A cross-sectional study to assess the epidemiological situation and associated risk factors of dengue fever; knowledge, attitudes, and practices about dengue prevention in Khyber Pakhtunkhwa Province, Pakistan. Front Public Health. 2022;29(10):923:37. DOI: https://www.doi:10.3389/fpubh.2022.923277 DOI: https://doi.org/10.3389/fpubh.2022.923277
García Gómez, Rodríguez Morales O, Fernández González CT, Rodríguez Roque MO. Evolución clínico-epidemiológica de pacientes con diagnóstico de dengue. Medisur [Internet]. 2020 [acceso 26/12/2023];17(6):790-6. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1727-897X2019000600790&lng=es
Luque N, Cilloniz C, Pons MJ, Donaires F, Albornoz R, Mendocilla Risco M, et al. Características clínicas y epidemiológicas de las muertes por dengue durante un brote en el norte del Perú. Rev. perú. med. exp. salud pública. 2023;40(1):67-72. DOI: http://dx.doi.org/10.17843/rpmesp.2023.401.12148 DOI: https://doi.org/10.17843/rpmesp.2023.401.12148
Anker M, Arima Y. Male-female differences in the number of reported incident dengue fever cases in six Asian countries. Western Pac Surveill Response J. 2011;2(2):17-23. DOI: http://dx.doi.org/10.5365/WPSAR.2011.2.1.002 DOI: https://doi.org/10.5365/wpsar.2011.2.1.002
González Perrota N, Araya S, Lovera D, Martínez de Cuellar C, Arbo Sosa A. Características clínicas y de laboratorio en pacientes pediátricos ambulatorios con Fiebre Dengue. Pediatr. (Asunción) [Internet]. 2020 [acceso 26/12/2023]; 47(1):5-10. Disponible en: http://scielo.iics.una.py/scielo.php?script=sci_arttext&pid=S1683-98032020000100005&Ing=en DOI: https://doi.org/10.31698/ped.47012020002
Shrestha DB, Budhathoki P, Gurung B, Subedi S, Aryal S, Basukala A, et al. Epidemiology of dengue in SAARC territory: a systematic review and meta-analysis. Parasit Vectors. 2022;15(1):389-96. Disponible en: https://www.doi:10.1186/s13071-022-05409-1 DOI: https://doi.org/10.1186/s13071-022-05409-1
Chaloemwong J, Tantiworawit A. Useful clinical features and hematological parameters for the diagnosis of dengue infection in patients with acute febrile illness: a retrospective study. BMC Hematology [Internet]. 2020 [acceso 26/12/2023];15(3):380-9. Disponible en: https://pubmed.ncbi.nlm.nih.gov/30181881/
Castilho BM, Silva MT, Freitas ARR, Fulone I, Lopes LC. Factors associated with thrombocytopenia in patients with dengue fever: a retrospective cohort study. BMJ Open. 2020;10(9):e035120. DOI: http://dx.doi.org/10.1136/bmjopen-2019-035120 DOI: https://doi.org/10.1136/bmjopen-2019-035120
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Yoánderson Pérez Díaz, Rolando Rodríguez Puga, Melissa María Navarro Gómez, Yanira González Ronquillo, Luis Acao Francois, Yanet Pérez Guerrero

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
BJM protects Copyright at all times. However, it gives up part of the rights by displaying a Creative Commons License 4.0 (cc-by-nc), which allows the use of the work to share (copy and redistribute the material in any support or format) and adapt (transform and built from the material) as long as exclusive mention of the publication in the journal as the primary source is made. Under no circumstances, the work can be commercialized.





