Guillain Barré Syndrome in children and adolescents during epidemic outbreaks

Authors

DOI:

https://doi.org/10.61997/bjm.v14i2.456

Keywords:

Epidemics, Guillain-Barre Syndrome, Pediatrics

Abstract

Background: Guillain-Barré syndrome is a rapidly progressive and immune-mediated polyneuropathy, rare in pediatrics, and is the most common cause of acute flaccid paralysis in childhood; the incidence is estimated at 0.34 to 1.34 per 100,000 people per year; Generally, it is associated with a history of infectious processes prior to the onset of motor symptoms in up to 50%-82% of cases. Objective: To generate an updated review on Guillain Barré Syndrome in children and adolescents and its relationship with the increase in cases in outbreaks of infectious diseases. Methods: A search of references published in the pubmed.gov database was carried out, period 2019-2024 in English, a total of 388 publications were obtained, selecting a total of n=47 that were included in this review and n=3 national reference publications. Those publications such as in response to, letters to the editor or editorial were excluded. Conclusion: Guillain Barré Syndrome is a rare condition in children and adolescents; however, it is the main cause of flaccid paralysis in childhood, with evidence in the literature about the increase in cases during epidemics, particularly those of a viral type such as arboviruses and recently SARS CoV-2.

Downloads

Download data is not yet available.

References

Levison LS, Thomsen RW, Markvardsen LK, Christensen DH, Sindrup SH, Andersen H. Pediatric Guillain-Barre Syndrome in a 30-Year Nationwide Cohort. Pediatr Neurol. 2020;107:57-63. doi: 10.1016/j.pediatrneurol.2020.01.017 DOI: https://doi.org/10.1016/j.pediatrneurol.2020.01.017

Shahrizaila N, Lehmann HC, Kuwabara S. Guillain-Barre syndrome. Lancet. 2021; 397(10280):1214-28. doi: 10.1016/S0140-6736(21)00517-1 DOI: https://doi.org/10.1016/S0140-6736(21)00517-1

Pimentel V, Luchsinger VW, Carvalho GL, Alcara AM, Esper NB, Marinowic D, et al. Guillain-Barre syndrome associated with COVID-19: A systematic review. Brain Behav Immun Health. 2023; 28:100578. doi: 10.1016/j.bbih.2022.100578 DOI: https://doi.org/10.1016/j.bbih.2022.100578

Korinthenberg R, Trollmann R, Felderhoff-Muser U, Bernert G, Hackenberg A, Hufnagel M, et al. Diagnosis and treatment of Guillain-Barre Syndrome in childhood and adolescence: An evidence- and consensus-based guideline. Eur J Paediatr Neurol. 2020; 25:5-16. doi: 10.1016/j.ejpn.2020.01.003 DOI: https://doi.org/10.1016/j.ejpn.2020.01.003

Prashanth A, Shende V, Pawar S. A Study of Sensory Nerve Conduction in Pre- and Post-immunoglobulin Treatment of Guillain-Barre Syndrome. Cureus. 2024; 16(1):e51673. doi: 10.7759/cureus.51673 DOI: https://doi.org/10.7759/cureus.51673

Organización Mundial de la Salud. Síndrome de Guillain-Barré. Ginebra, Suiza: OMS, 2023. Disponible en: https://www.who.int/es/news-room/fact-sheets/detail/guillain-barré-syndrome

Al Jaberi M, Shihadat R, Masri A. Post SARS-CoV-2 Guillain-Barre syndrome in a child: case report and review of the literature. Childs Nerv Syst. 2022; 38(10):2011-6. doi: 10.1007/s00381-022-05536-1 DOI: https://doi.org/10.1007/s00381-022-05536-1

Wachira VK, Farinasso CM, Silva RB, Peixoto HM, de Oliveira MRF. Incidence of Guillain-Barre syndrome in the world between 1985 and 2020: A systematic review. Glob Epidemiol. 2023; 5:100098. doi: 10.1016/j.gloepi.2023.100098 DOI: https://doi.org/10.1016/j.gloepi.2023.100098

Leonhard SE, Mandarakas MR, Gondim FAA, Bateman K, Ferreira MLB, Cornblath DR, et al. Diagnosis and management of Guillain-Barre syndrome in ten steps. Nat Rev Neurol. 2019; 15(11):671-83. doi: 10.1038/s41582-019-0250-9 DOI: https://doi.org/10.1038/s41582-019-0250-9

Abu-Rumeileh S, Abdelhak A, Foschi M, Tumani H, Otto M. Guillain-Barre syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cases. J Neurol. 2021; 268(4):1133-70. doi: 10.1007/s00415-020-10124-x DOI: https://doi.org/10.1007/s00415-020-10124-x

Langille MM. Guillain-Barre Syndrome in Children and Adolescents. Adv Pediatr. 2023; 70(1):91-103. doi: 10.1016/j.yapd.2023.04.001 DOI: https://doi.org/10.1016/j.yapd.2023.04.001

Li Y, Zhao R, Li L, Xue H, Meng H, Li G, et al. Relative frequencies and clinical features of Guillain-Barré Syndrome before and during the COVID-19 pandemic in North China. BMC Infectious Diseases. 2024; 24(1):541-8. doi: 10.1186/s12879-024-09401-1 DOI: https://doi.org/10.1186/s12879-024-09401-1

Omura S, Shimizu K, Kuwahara M, Morikawa-Urase M, Kusunoki S, Tsunoda I. Exploratory factor analysis determines latent factors in Guillain-Barre syndrome. Sci Rep. 2022; 12(1):21837. doi: 10.1038/s41598-022-26422-5 DOI: https://doi.org/10.1038/s41598-022-26422-5

Cavirani B, Baga M, Cesaroni CA, Rizzi S, Spagnoli C, Frattini D, et al. Guillain-Barre Syndrome-Retrospective Analysis of Data from a Cohort of Patients Referred to a Tertiary Care Pediatric Neuromuscular Center from 2000 to 2017: Electrophysiological Findings, Outcomes, and a Brief Literature Review. Medicina (Kaunas). 2024; 60(9). doi: 10.3390/medicina60091490 DOI: https://doi.org/10.3390/medicina60091490

Rangan RS, Tullu MS, Deshmukh CT, Mondkar SA, Agrawal M. Clinical Profile and Outcome of Guillain-Barre Syndrome in Pediatric Patients Admitted to a Tertiary Care Centre: A Retrospective Study. Neurol India. 2021; 69(1):81-4. doi: 10.4103/0028-3886.310112 DOI: https://doi.org/10.4103/0028-3886.310112

Helfferich J, Roodbol J, de Wit MC, Brouwer OF, Jacobs BC, Enterovirus DAFMWG, et al. Acute flaccid myelitis and Guillain-Barre syndrome in children: A comparative study with evaluation of diagnostic criteria. Eur J Neurol. 2022; 29(2):593-604. doi: 10.1111/ene.15170 DOI: https://doi.org/10.1111/ene.15170

Florian IA, Lupan I, Sur L, Samasca G, Timis TL. To be, or not to be... Guillain-Barre Syndrome. Autoimmun Rev. 2021; 20(12):102983. doi: 10.1016/j.autrev.2021.102983 DOI: https://doi.org/10.1016/j.autrev.2021.102983

Ashrafi MR, Mohammadalipoor A, Naeini AR, Amanat M, Tavasoli AR, Heidari M, et al. Clinical Characteristics and Electrodiagnostic Features of Guillain-Barre Syndrome Among the Pediatric Population. J Child Neurol. 2020; 35(7):448-55. doi: 10.1177/0883073820905157 DOI: https://doi.org/10.1177/0883073820905157

Wahatule R, Dutta D, Debnath M, Nagappa M, Mahadevan A, Sinha S, et al. Ganglioside complex antibodies in an Indian cohort of Guillain-Barre syndrome. Muscle Nerve. 2020; 62(6):728-34. doi: 10.1002/mus.27071 DOI: https://doi.org/10.1002/mus.27071

Javankiani S, Nasrollahizadeh A, Gharib B, Heidari M, Memarian S. The characteristics of Guillain-Barre syndrome in children in pre-COVID-19 and during the COVID-19 pandemic: A cross-sectional study. Health Sci Rep. 2023; 6(12):e1782. doi: 10.1002/hsr2.1782 DOI: https://doi.org/10.1002/hsr2.1782

Luo HY, Li XJ, Cheng M, Wang J, Xie LL, Yao ZX, et al. Clinical characteristics of children with Guillain-Barre syndrome and factors associated with disease severity. J Clin Neurosci. 2021; 92:120-5. doi: 10.1016/j.jocn.2021.08.001 DOI: https://doi.org/10.1016/j.jocn.2021.08.001

Galeas Oliva M, Ramos F. Síndrome de Guillain Barré Recurrente: Reporte de caso. Acta Pediátrica Hondureña. 2017; 8(2):791-5. Disponible en: http://www.bvs.hn/APH/pdf/APHVol8/pdf/APHVol8-2-2017-2018-6 DOI: https://doi.org/10.5377/pediatrica.v8i2.7980

Sreelakshmi V, Pattanaik A, Marate S, Mani RS, Pai AR, Mukhopadhyay C. Guillain-barre syndrome (GBS) with antecedent chikungunya infection: a case report and literature review. Neurol Res Pract. 2024; 6(1):21. doi: 10.1186/s42466-024-00315-6 DOI: https://doi.org/10.1186/s42466-024-00315-6

Sharma P, Surve RM, Pendharkar HS, Kulkarni GB, Naik SS. Mimics of Guillain-Barre Syndrome in Pediatric Patients Admitted to the Neuro-Intensive Care Unit of a Tertiary Care Hospital-A Case Series. Neurol India. 2024; 72(2):379-83. doi: 10.4103/ni.ni_881_22 DOI: https://doi.org/10.4103/ni.ni_881_22

Dutta D, Debnath M, Seshagiri DV, Nair BVS, Das SK, Wahatule R, et al. Impact of Antecedent Infections on the Antibodies against Gangliosides and Ganglioside Complexes in Guillain-Barre Syndrome: A Correlative Study. Ann Indian Acad Neurol. 2022; 25(3):401-6. doi: 10.4103/aian.aian_121_22 DOI: https://doi.org/10.4103/aian.aian_121_22

Censi S, Bisaccia G, Gallina S, Tomassini V, Uncini A. Guillain-Barre syndrome and SARS-CoV-2 infection: a systematic review and meta-analysis on a debated issue and evidence for the 'Italian factor'. Eur J Neurol. 2024; 31(2):e16094. doi: 10.1111/ene.16094 DOI: https://doi.org/10.1111/ene.16094

Li X, Yang L, Wang G, Yuan Y, Wei N, Yang W, et al. Extensive cytokine biomarker analysis in serum of Guillain-Barre syndrome patients. Sci Rep. 2023; 13(1):8354. doi: 10.1038/s41598-023-35610-w DOI: https://doi.org/10.1038/s41598-023-35610-w

Frank CHM, Almeida TVR, Marques EA, de Sousa Monteiro Q, Feitoza PVS, Borba MGS, et al. Guillain-Barre Syndrome Associated with SARS-CoV-2 Infection in a Pediatric Patient. J Trop Pediatr. 2021; 67(3). doi: 10.1093/tropej/fmaa044 DOI: https://doi.org/10.1093/tropej/fmaa044

Manji HK, George U, Mkopi NP, Manji KP. Guillain-Barre syndrome associated with COVID-19 infection. Pan Afr Med J. 2020; 35(Suppl 2):118. doi: 10.11604/pamj.supp.2020.35.2.25003

Malamud E, Caress JB, Lapid DJ, Otallah SI. "Guillain-Barre Syndrome After COVID-19 Vaccination in an Adolescent" [Pediatric Neurology, Volume 126, January 2022, Pages 9-10]. Pediatr Neurol. 2022; 128:77. doi: 10.1016/j.pediatrneurol.2021.11.001 DOI: https://doi.org/10.1016/j.pediatrneurol.2021.11.001

Curtis M, Bhumbra S, Felker MV, Jordan BL, Kim J, Weber M, et al. Guillain-Barre Syndrome in a Child With COVID-19 Infection. Pediatrics. 2021; 147(4). doi: 10.1542/peds.2020-015115 DOI: https://doi.org/10.1542/peds.2020-015115

Akcay N, Menentoglu ME, Bektas G, Sevketoglu E. Axonal Guillain-Barre syndrome associated with SARS-CoV-2 infection in a child. J Med Virol. 2021; 93(9):5599-602. doi: 10.1002/jmv.27018 DOI: https://doi.org/10.1002/jmv.27018

Olbert E, Alhani N, Struhal W. Retrospective analysis of COVID-19 patients with Guillain-Barre, Miller-Fisher, and opsoclonus-myoclonus-ataxia syndromes-a case series. Wien Med Wochenschr. 2024; 174(1-2):30-4. doi: 10.1007/s10354-023-01018-4 DOI: https://doi.org/10.1007/s10354-023-01018-4

Martinelli-Boneschi F, Colombo A, Bresolin N, Sessa M, Bassi P, Grampa G, et al. COVID-19-associated Guillain-Barre syndrome in the early pandemic experience in Lombardia (Italy). Neurol Sci. 2023; 44(2):437-46. doi: 10.1007/s10072-022-06429-6 DOI: https://doi.org/10.1007/s10072-022-06429-6

Hagen KM, Ousman SS. The Neuroimmunology of Guillain-Barre Syndrome and the Potential Role of an Aging Immune System. Front Aging Neurosci. 2020; 12:613628. doi: 10.3389/fnagi.2020.613628 DOI: https://doi.org/10.3389/fnagi.2020.613628

van Doorn PA, Van den Bergh PYK, Hadden RDM, Avau B, Vankrunkelsven P, Attarian S, et al. European Academy of Neurology/Peripheral Nerve Society Guideline on diagnosis and treatment of Guillain-Barre syndrome. Eur J Neurol. 2023; 30(12):3646-74. doi: 10.1111/ene.16073 DOI: https://doi.org/10.1111/ene.16073

Scallan Walter EJ, Crim SM, Bruce BB, Griffin PM. Incidence of Campylobacter-Associated Guillain-Barre Syndrome Estimated from Health Insurance Data. Foodborne Pathog Dis. 2020; 17(1):23-8. doi: 10.1089/fpd.2019.2652 DOI: https://doi.org/10.1089/fpd.2019.2652

Dutta D, Debnath M, Nagappa M, Das SK, Wahatule R, Sinha S, et al. Antecedent infections in Guillain-Barre syndrome patients from south India. J Peripher Nerv Syst. 2021; 26(3):298-306. doi: 10.1111/jns.12459 DOI: https://doi.org/10.1111/jns.12459

Estublier B, Colineaux H, Arnaud C, Cintas P, Baudou E, Chaix Y, et al. Long-term outcomes of paediatric Guillain-Barre syndrome. Dev Med Child Neurol. 2024; 66(2):176-86. doi: 10.1111/dmcn.15693 DOI: https://doi.org/10.1111/dmcn.15693

Sen S, Kumar A, Roy B. Clinical Outcome of Guillain-Barre Syndrome in 108 Children. Indian Pediatr. 2021; 58(9):833-5. doi: 10.1007/s13312-021-2302-7 DOI: https://doi.org/10.1007/s13312-021-2302-7

Garnero M, Del Sette M, Assini A, Beronio A, Capello E, Cabona C, et al. COVID-19-related and not related Guillain-Barre syndromes share the same management pitfalls during lock down: The experience of Liguria region in Italy. J Neurol Sci. 2020; 418:117114. doi: 10.1016/j.jns.2020.117114 DOI: https://doi.org/10.1016/j.jns.2020.117114

Aladawi M, Elfil M, Abu-Esheh B, Abu Jazar D, Armouti A, Bayoumi A, et al. Guillain Barre Syndrome as a Complication of COVID-19: A Systematic Review. Can J Neurol Sci. 2022; 49(1):38-48. doi: 10.1017/cjn.2021.102 DOI: https://doi.org/10.1017/cjn.2021.102

Christie CDC, Lue AM, Melbourne-Chambers RH. Dengue, chikungunya and zika arbovirus infections in Caribbean children. Curr Opin Pediatr. 2023; 35(2):155-65. doi: 10.1097/MOP.0000000000001229 DOI: https://doi.org/10.1097/MOP.0000000000001229

Leung J, Sejvar JJ, Soares J, Lanzieri TM. Guillain-Barre syndrome and antecedent cytomegalovirus infection, USA 2009-2015. Neurol Sci. 2020; 41(4):885-91. doi: 10.1007/s10072-019-04156-z DOI: https://doi.org/10.1007/s10072-019-04156-z

del Carpio Orantes L, Cerda Méndez C, Jiménez García R, Garma García A, López Cabrera Y, Flores Salguero L, et al. Síndrome de Guillain Barré asociado a los brotes de Zika, deBrasil a México. Neurología Argentina. 2020; 12(3):147-52. doi: 10.1016/j.neuarg.2020.06.002 DOI: https://doi.org/10.1016/j.neuarg.2020.06.002

Ramírez Izcoa A, Izaguirre González A, Cerna Lizardo J, Hernandez Bustillo G, Cordova Tello D. Síndrome de Guillain Barré en paciente pediátrico: Diagnóstico y Rehabilitación. Reporte de caso. Rev Med Hondur. 2016; 84(3 y 4):118-22. Disponible en: https://camjol.info/index.php/RMH/article/view/12380

Zavala C, Aguilera G. Síndrome de Guillain Barre Crónico o Recurrente. Rev Med Hondur. 1996;64(4):149-52. Disponible en: https://pesquisa.bvsalud.org/portal/resource/pt/lil-200255

Sudeep KC, Bansal A, Randhawa MS, Muralidharan J, Nallasamy K, Angurana SK, et al. Recurrent Guillain-Barre Syndrome: Clinical Profile and Outcome. Indian J Pediatr. 2024; 91(5):448-54. doi: 10.1007/s12098-023-04746-y DOI: https://doi.org/10.1007/s12098-023-04746-y

Rajurkar RD, Patil DS, Jagzape MV. Pediatric Physiotherapeutic Approach for Guillain-Barre Syndrome Associated With Dengue Fever: A Case Report. Cureus. 2023; 15(10):e46488. doi: 10.7759/cureus.46488 DOI: https://doi.org/10.7759/cureus.46488

Chafiq K, Hadzine Y, Elmekkaoui A, Benlenda O, Rajad H, Wakrim S, et al. Navigating the complexity of Guillain-Barre syndrome and Miller-Fisher syndrome overlap syndrome: a pediatric case report. Pan Afr Med J. 2024; 47:127. doi: 10.11604/pamj.2024.47.127.42985 DOI: https://doi.org/10.11604/pamj.2024.47.127.42985

Published

02-05-2025

How to Cite

Ramos Ortega, A. E., & Miralda Méndez, S. T. (2025). Guillain Barré Syndrome in children and adolescents during epidemic outbreaks. Belize Journal of Medicine, 14(2). https://doi.org/10.61997/bjm.v14i2.456