Antiphospholipid Syndrome in Pregnancy

Abstract

Antiphospholipid Syndrome is associated in pregnancy with repeat abortions and fetal loss; other frequently reported complications are preeclampsia and placental insufficiency. The pathogenesis of fetal losses in the APS is due to the thrombophilic effect caused by the presence of antibodies against phospholipids and to other mechanisms that include direct effects on the trophoblast and inflammatory phenomena. Accurate laboratory identification is a fundamental pillar in differential diagnosis of other obstetric pathologies. The combination of a very detailed and close follow up in conjunction with an established treatment will result in a successful pregnancy.