SARS-CoV-2 infection in children managed at a non-COVID tertiary hospital in Tegucigalpa, Honduras

Authors

DOI:

https://doi.org/10.61997/bjm.v14i2.475

Keywords:

COVID-19, Severe acute respiratory syndrome-related coronavirus, Coronavirus infections, SARS-CoV-2

Abstract

Background: SARS-CoV-2 in children represents 2 %-5 % of all cases; it is generally asymptomatic, although some patients may present with severe disease requiring admission to a Pediatric Intensive Care Unit and assisted ventilation due to complications, mainly severe pneumonia. Objective: To characterize children diagnosed with SARS-CoV-2 infection treated at a non-COVID tertiary hospital. Methods: Retrospective, descriptive, cross-sectional study was carried out in the Pediatric Emergency Department of the Escuela Hospital, Tegucigalpa, Honduras, from January 2021 to December 2022. The sample consisted of 66 patients, of which 47 met the inclusion criteria. Results: Average age 51.0 months (+/-61.9; r: 10 months-17 years); male sex was more frequent at 59.6% (28/47). Comorbidity was present in 20 patients (42.6%); the main symptoms were fever (87.2% (41/47), cough (68.1% (32/47), and diarrhea (27.7% (13/47). Leukocytosis was reported to 59.6% (28/47), neutrophilia in 63.8% (30/47), and lymphopenia (46.7%; 22/47). Treatment included ceftriaxone in 48.9% (23/47) and intravenous fluids in 21.2% (10/47). Complications were present in 28 cases (59.6%), mainly severe pneumonia. A total of 10.6% (5/47) were admitted to the Pediatric Intensive Care Unit; two patients (4.3%) died. Conclusion: SARS-CoV-2 infection in pediatric patients treated at a non-COVID tertiary care hospital is consistent with that described in the literature; the clinical picture may be mild, although the risk of severe disease may be higher in those with comorbidities.

Downloads

Download data is not yet available.

References

Bogiatzopoulou A, Mayberry H, Hawcutt DB, Whittaker E, Munro A, Roland D, et al. COVID-19 in children: what did we learn from the first wave? Paediatr Child Health. 2020; 30(12):438-43. doi: 10.1016/j.paed.2020.09.005 DOI: https://doi.org/10.1016/j.paed.2020.09.005

Chang TH, Wu JL, Chang LY. Clinical characteristics and diagnostic challenges of pediatric COVID-19: A systematic review and meta-analysis. J Formos Med Assoc. 2020; 119(5):982-9. doi: 10.1016/j.jfma.2020.04.007 DOI: https://doi.org/10.1016/j.jfma.2020.04.007

Pokorska-Spiewak M, Talarek E, Mania A, Pawlowska M, Popielska J, Zawadka K, et al. Clinical and Epidemiological Characteristics of 1283 Pediatric Patients with Coronavirus Disease 2019 during the First and Second Waves of the Pandemic-Results of the Pediatric Part of a Multicenter Polish Register SARSTer. J Clin Med. 2021; 10(21). doi: 10.3390/jcm10215098 DOI: https://doi.org/10.3390/jcm10215098

Yoon S, Li H, Lee KH, Hong SH, Kim D, Im H, et al. Clinical Characteristics of Asymptomatic and Symptomatic Pediatric Coronavirus Disease 2019 (COVID-19): A Systematic Review. Medicina (Kaunas). 2020; 56(9). doi: 10.3390/medicina56090474 DOI: https://doi.org/10.3390/medicina56090474

Alharbi M, Kazzaz YM, Hameed T, Alqanatish J, Alkhalaf H, Alsadoon A, et al. SARS-CoV-2 infection in children, clinical characteristics, diagnostic findings and therapeutic interventions at a tertiary care center in Riyadh, Saudi Arabia. J Infect Public Health. 2021; 14(4):446-53. doi: 10.1016/j.jiph.2020.12.034 DOI: https://doi.org/10.1016/j.jiph.2020.12.034

Castagnoli R, Votto M, Licari A, Brambilla I, Bruno R, Perlini S, et al. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children and Adolescents: A Systematic Review. JAMA Pediatr. 2020; 174(9):882-9. doi: 10.1001/jamapediatrics.2020.1467 DOI: https://doi.org/10.1001/jamapediatrics.2020.1467

Wurzel D, McMinn A, Hoq M, Blyth CC, Burgner D, Tosif S, et al. Prospective characterisation of SARS-CoV-2 infections among children presenting to tertiary paediatric hospitals across Australia in 2020: a national cohort study. BMJ Open. 2021; 11(11):e054510. doi: 10.1136/bmjopen-2021-054510 DOI: https://doi.org/10.1136/bmjopen-2021-054510

Liguoro I, Pilotto C, Bonanni M, Ferrari ME, Pusiol A, Nocerino A, et al. SARS-COV-2 infection in children and newborns: a systematic review. Eur J Pediatr. 2020; 179(7):1029-46. doi: 10.1007/s00431-020-03684-7 DOI: https://doi.org/10.1007/s00431-020-03684-7

Rajapakse N, Dixit D. Human and novel coronavirus infections in children: a review. Paediatr Int Child Health. 2021; 41(1):36-55. doi: 10.1080/20469047.2020.1781356 DOI: https://doi.org/10.1080/20469047.2020.1781356

Borel M, Xie L, Kapera O, Mihalcea A, Kahn J, Messiah SE. Long-term physical, mental and social health effects of COVID-19 in the pediatric population: a scoping review. World J Pediatr. 2022; 18(3):149-59. doi: 10.1007/s12519-022-00515-7 DOI: https://doi.org/10.1007/s12519-022-00515-7

Fernandez-Sarmiento J, De Souza D, Jabornisky R, Gonzalez GA, Arias Lopez MDP, Palacio G. Paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): a narrative review and the viewpoint of the Latin American Society of Pediatric Intensive Care (SLACIP) Sepsis Committee. BMJ Paediatr Open. 2021; 5(1):e000894. doi: 10.1136/bmjpo-2020-000894 DOI: https://doi.org/10.1136/bmjpo-2020-000894

Alteri C, Scutari R, Costabile V, Colagrossi L, Yu La Rosa K, Agolini E, et al. Epidemiological characterization of SARS-CoV-2 variants in children over the four COVID-19 waves and correlation with clinical presentation. Sci Rep. 2022;12(1):10194. doi: 10.1038/s41598-022-14426-0 DOI: https://doi.org/10.1038/s41598-022-14426-0

Rudan I, Adeloye D, Katikireddi SV, Murray J, Simpson C, Shah SA, et al. The COVID-19 pandemic in children and young people during 2020-2021: Learning about clinical presentation, patterns of spread, viral load, diagnosis and treatment. J Glob Health. 2021; 11:01010. doi: 10.7189/jogh.11.01010 DOI: https://doi.org/10.7189/jogh.11.01010

Sorg AL, Hufnagel M, Doenhardt M, Diffloth N, Schroten H, von Kries R, et al. Risk for severe outcomes of COVID-19 and PIMS-TS in children with SARS-CoV-2 infection in Germany. Eur J Pediatr. 2022; 181(10):3635-43. doi: 10.1007/s00431-022-04587-5 DOI: https://doi.org/10.1007/s00431-022-04587-5

Uka A, Buettcher M, Bernhard-Stirnemann S, Fougere Y, Moussaoui D, Kottanattu L, et al. Factors associated with hospital and intensive care admission in paediatric SARS-CoV-2 infection: a prospective nationwide observational cohort study. Eur J Pediatr. 2022; 181(3):1245-55. doi: 10.1007/s00431-021-04276-9 DOI: https://doi.org/10.2139/ssrn.3823127

Whittaker E, Bamford A, Kenny J, Kaforou M, Jones CE, Shah P, et al. Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2. JAMA. 2020; 324(3):259-69. doi: 10.1001/jama.2020.10369 DOI: https://doi.org/10.1001/jama.2020.10369

Ramcharan T, Nolan O, Lai CY, Prabhu N, Krishnamurthy R, Richter AG, et al. Paediatric Inflammatory Multisystem Syndrome: Temporally Associated with SARS-CoV-2 (PIMS-TS): Cardiac Features, Management and Short-Term Outcomes at a UK Tertiary Paediatric Hospital. Pediatr Cardiol. 2020; 41(7):1391-401. doi: 10.1007/s00246-020-02391-2 DOI: https://doi.org/10.1007/s00246-020-02391-2

Toraih EA, Hussein MH, Elshazli RM, Kline A, Munshi R, Sultana N, et al. Multisystem inflammatory syndrome in pediatric COVID-19 patients: a meta-analysis. World J Pediatr. 2021; 17(2):141-51. doi: 10.1007/s12519-021-00419-y DOI: https://doi.org/10.1007/s12519-021-00419-y

Harwood R, Allin B, Jones CE, Whittaker E, Ramnarayan P, Ramanan AV, et al. A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a national Delphi process. Lancet Child Adolesc Health. 2021;5(2):133-41. doi: 10.1016/S2352-4642(20)30304-7 DOI: https://doi.org/10.1016/S2352-4642(20)30304-7

Gallo Marin B, Aghagoli G, Lavine K, Yang L, Siff EJ, Chiang SS, et al. Predictors of COVID-19 severity: A literature review. Rev Med Virol. 2021; 31(1):1-10. doi: 10.1002/rmv.2146 DOI: https://doi.org/10.1002/rmv.2146

Published

02-05-2025

How to Cite

Miralda Méndez, S. T., Flores Hernández, G. A., & Zelaya Maradiaga, O. J. (2025). SARS-CoV-2 infection in children managed at a non-COVID tertiary hospital in Tegucigalpa, Honduras. Belize Journal of Medicine, 14(2). https://doi.org/10.61997/bjm.v14i2.475

Issue

Section

Original